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Kaalika Palace Group

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Jayden Nguyen
Jayden Nguyen

CR-Scan Ferret: A Portable and Affordable 3D Scanner for Ferret Lovers



Creality CR-Scan Ferret 3D Scanner 2023 New Arrivals, An improvement over its predecessor CR-Scan Lizard. EASY SCAN & Support more scene. More playability. You'll be able to use Ferret anywhere, indoors or out, to scan objects.


Wide-range scanning, and High-accuracy scanningThe two modes can be changed according to the requirements of the user. Wide-range mode rapidly scans large objects. It consists of a single capture range of up to 560*820mm, covering a large area and allowing users to modify the distance for medium and large objects. Users do not need to apply anything to the objects prior to scanning, i.e., it tracks them automatically. High-accuracy mode precisely scans medium-to-small-sized objects. It features a 0.1mm accuracy and a 3D resolution of 0.16mm, ensuring high quality and capturing more details.




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Built-in camera with high-resolution color camera, Present the Original ColorSupporting to captures full-color textures of objects and present the original color of the object. It allows the users to produce high-quality, vivid color scans that reflect the real color of the world that the users scanned.


EASY CONNECT, EASY CHARGE & FAST SCANNING- Integrated Circuit (ASIC) depth computing chip to keep a scanning frame rate of up to 30fps for seamless and rapid scanning with little workload and lower power consumption.- Compatible with computer and phone. - Low power consumption so it can be powered by a 5V power bank, and even your android phone. Start scanning at any time.


APP SUPPORTEDCreality has developed a special Scan APP and software to cooperate with CR-Scan Ferret. With user-friendly functions such as one-click model optimization, multi-position automatic alignment, automatic noise removal, simplified topology and color texture mapping, users can easily achieve a clear scan and complete the model.


Ferrets are an active and social animal, so it is important to help them stay active by playing and spending time with them. Ferrets are curious, often very mischievous, and naturally inquisitive with a taste for adventure. They each have distinctively individual personalities. They have a short attention span and are constantly seeking new and more exciting things to explore and experience. Also, ferrets must have a secure play and living area.


Like children, ferrets love to play with small toys. Balls, squeakers, and little stuffed animals can keep ferrets amused for hours. Make sure toys are of good, strong plastic and have no small pieces (such as eyes) that can be chewed off and swallowed.


Keeping a ferret caged too long will lead to an unhappy and stressed pet. Prolonged caging may result in negative activities once the ferret is finally free, such as hiding on you; poor socialization with other pets, and nipping. A ferret without proper stimulation can also get depressed, which usually leads to apathy, bad habits, decreased appetite, poor coat, and other health issues.


A cohort of six control and six KY/180-infected ferrets were examined for A) body weight and B) temperature over a period of 10 days. C) Blood was examined for the presence of HI and antibody titers at 14 days.


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By 1 DPI, an area of consolidation was identified on CT in the right caudal lobe with corresponding radiotracer uptake on PET (Fig. 2B, SUVMax of 4.7). Consolidative areas in the right caudal lobe increased by day 2, with a persistently elevated SUVMax of 3.1(data not shown). By day 3, the consolidation increased in the right caudal lobe (Fig. 2C and Fig. 3C, SUVMax of 3.7 and 4.4, respectively) and also appeared in the left caudal lobe (SUVMax of 3.2) of ferret 2214 (Fig. 3C). By 6 DPI, there were widespread areas of patchy consolidation on CT with multiple areas of increased radiotracer uptake in both ferrets in caudal and cranial lobes (Fig. 2D and Fig. 3D, SUVMax of 6.0 and 7.6 on the right, 4.2 and 4.6 on the left, respectively). These results suggest that inflammation progresses into the lower respiratory airways after infection into the upper part of the lower respiratory system. A ferret from the uninfected cohort was also imaged on day 6, with no focal appearance of consolidation on CT and no evidence of increased [18F]-FDG uptake on PET (image not shown, background SUV of 0.6).


To measure viral shedding, each day each ferret was swabbed in the nasal, throat and fecal passages and the viral titer was measured by TCID50 (Table 2). The highest levels of viral shedding were measured in the throat swabs. Nasal swabs also showed viral shedding for most animals, while the presence of virus in rectal swabs was low although detectable in a few animals.


The right caudal lobe of each ferret was divided into 4 sections, A (top), B (middle), C (middle-lower) and D (bottom) for measurement of viral replication. Please refer to table 3 for viral replication titers measured from each tissue section.


Upon necropsy, all but the right caudal lobe of the ferret lung was fixed with paraformaldehyde. Following fixation, sections were taken for histopathology from the right and left cranial lobes, left caudal lobe and the middle accessory lobe. Representative photographs from slides of the left caudal lobe are shown in figure 5. The ferrets in the control group had intact bronchiolar walls with very minimal infiltration by neutrophils with the exception of the left caudal lobe from control animal 2206 sacrificed on Day 1. Possible causes of this pattern of change may be an underlying systemic vasculopathy which is typically confirmed by evaluation of other organs that were not collected (e.g., kidney, spleen, liver).


In general pulmonary lesions associated with influenza infection were roughly comparable at Days 1 and 2 and consisted of variable suppurative or necrosuppurative bronchiolitis and mixed cell alveolitis at minimal to moderate severity levels. By 1 DPI, there were some small foci of inflammation without much infiltration of the bronchi or bronchioles. There was an increased severity of inflammatory findings in lung lobes from infected ferrets on day 3. Specifically, more extensive infiltration of neutrophils can be seen within the bronchiolar lumen, along with necrosupprative bronchiolitis and mixed cell alveolitis. At Day 7, lesions observed in the lung lobes continued to exhibit an increased severity compared to the majority of lung lesions seen at 1 and 2 DPI. Bronchiolar epithelial hyperplasia and cytokaryomegaly were noted in addition to bronchiolitis.


Noninvasive imaging can provide real-time in vivo monitoring of the progression of infection, inflammation and disease that may give insight into the mechanisms that modulate disease progression. Recently, Veldhuis Kroeze et al, presented data on the monitoring of pulmonary lesions of H1N1pdm influenza virus-infected ferrets with CT scanning which correlated with disease progression and severity [44]. As those studies demonstrate, CT is a powerful tool, but it will not give the molecular details that can be provided by PET or SPECT imaging of probes that target critical host responses such as neutrophil invasion. In our study we coupled CT scanning with the [18F]-FDG radiotracer and show infection and inflammation of influenza infection in the lower respiratory system with foci of increased [18F]-FDG uptake corresponding to areas of lung opacity on CT, with underlying inflammation on necropsy. In comparison to human CT imaging studies of influenza, the molecular images in the ferret show strong similarity. CT findings in patients with confirmed influenza infection show patchy ground-glass opacities in segmental multifocal distributions, mixed with areas of consolidation in the lung [12], [25], [45]. Moreover, the few case reports of human influenza in which lungs were imaged by [18F]-FDG PET demonstrate areas of high uptake in these ground-glass opacities and consolidation [31]. Our study similarly demonstrates this pattern in the ferret model, also showing patchy opacities on CT with high uptake of radiotracer on PET, with necroscopy-based confirmation of inflammation in the left caudal lobe. Specifically, we show the ferret lung demonstrated progressive consolidation on CT and FDG uptake on PET predominantly in the right caudal lobe, which progressed to the left caudal lobe by day 3 p.i. By day 6, the diffuse metabolically active lesions seen on PET/CT were similar to what has been reported in the human literature during the 2009 H1N1 pandemic [31].


Ultimately, utilizing these new imaging tools, we envision a number of future experiments to delineate potential differences in the course of H1N1pdm and H5N1 infection in ferrets. We also plan to explore additional radiotracers that might reveal potential differences in host responses in the immune system and the process of acute injury in the lung. Future studies will assess differences in presentation of those who recover from infection versus those who eventually succumb to infection such as with more lethal isolates such as H5N1. This model should be valuable in rapid assessment of the effect of various treatments on pulmonary inflammation and damage. Finally, these first PET/CT imaging approaches could be extended to a number of other important pulmonary infections caused by pathogens such as hantaviruses, respiratory syncytial virus, and SARS CoV, to gain further insight into the spatiotemporal in vivo dynamics of disease progression [18].


All female Fitch ferrets were obtained from Triple F Farms (Sayre, PA). Ferrets were selected after screening blood samples for the presence of influenza antibodies using a hemagglutination inhibition assay (HI). Ferrets that were seronegative for seasonal and pandemic viruses were shipped directly to the University of Louisville Regional Biocontainment Laboratory and acclimated for seven days prior to initiation of the studies. Animals were fed Teklad Laboratory Diet #2072 (Harlan/Teklad, Madison, WI) and water ad libitum.


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